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Hyperbaric oxygen therapy reveals promise for opioid addiction medicine

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Hyperbaric oxygen therapy can also merely help folks being treated for opioid addiction minimize their methadone dose and better field up misfortune and withdrawal symptoms, in step with a pair of evaluate led by Washington Issue College scientists.

The evaluate team recruited participants enrolled in a neighborhood opioid medicine program to take a look at the outcomes of , a medications that entails breathing pure oxygen in a pressurized environment.

Printed in the Journal of Addictions Nursing, the well-known paper describes a of 31 participants that showed that these that had got hyperbaric oxygen as piece of a planned methadone taper were ready to protect a vastly bigger dose discount of 4.3 mg three months after the see, as in comparison with 0.25 mg in participants who did no longer receive the therapy. They moreover reported half the stage of skilled by alter participants after totally in the future of hyperbaric oxygen therapy. 

“While methadone helps folks with gain staunch and resume their abnormal lives, or no longer it is unruffled an opioid that they’re taking on day by day basis,” acknowledged see co-author Matthew Layton, a professor in the WSU Elson S. Floyd College of Remedy and a frail opioid medicine program scientific director. “About half of folks in medicine are attempting to gain off of methadone for quite loads of reasons, but many who bask in tried bask in failed and relapsed. Our findings counsel that hyperbaric oxygen therapy can also doubtlessly be outdated as a non-pharmacological tool to help folks step down their methadone medicine.”

The 2d see, which became printed in Pain Administration Nursing, became a small randomized controlled trial of eight participants that appeared extra closely at withdrawal symptom reduction. It found that participants in the hyperbaric oxygen therapy medicine community reported decrease misfortune depth and drug cravings than alter participants who had been given an oxygen combination a much like room air delivered at abnormal atmospheric force. The researchers moreover saw improvements in a quantity of outcomes, much like sleep quality and mood.

“While for some the distance is to gain off methadone, others struggle to protect in medicine early on because discovering the suitable dose to stabilize symptoms will even be sophisticated to withhold out,” acknowledged first author Marian Wilson, an affiliate professor in the WSU College of Nursing and an knowledgeable on misfortune management opioid use dysfunction. “In consequence, hundreds of folks ride withdrawal symptoms in that adjustment interval that will even be extreme ample to own them resume unlawful drug use or tumble out of .”

Basically essentially based on the collective findings from the 2 evaluate, the researchers are pursuing funding for a scientific trial to substantiate their findings in a bigger sample of participants, who would be followed for quite loads of years.  

The concept that for the 2 evaluate came from earlier evaluate by one in every of the WSU researchers that showed that hyperbaric oxygen therapy supplied misfortune reduction and reduced bodily signs of opioid withdrawal in mice.

“We were anxious to sight if it may per chance per chance well well work in folks,” acknowledged see co-author Raymond Quock, a professor in the WSU College of Arts and Sciences, who led that work.

If their findings extend in a bigger scientific trial, hyperbaric therapy can also change into a non-pharmacological tool that suppliers can use to help folks field up misfortune and doubtlessly minimize their opioid use.

“Remaining twelve months, over 100,000 folks died as a outcomes of the opioid epidemic inner the COVID-19 pandemic,” acknowledged Layton. “That reveals us that addiction is unruffled a extremely nice effort, and we elect to bask in better techniques to scheme it.”



Extra data:
Marian Wilson et al, Hyperbaric Oxygen to Attend Adults With Opioid Yelp Dysfunction in Decreasing Methadone Dose, Journal of Addictions Nursing (2022). DOI: 10.1097/JAN.0000000000000447

Marian Wilson et al, Hyperbaric Oxygen Therapy for Pain, Opioid Withdrawal, and Connected Symptoms: A Pilot Randomized Controlled Trial, Pain Administration Nursing (2022). DOI: 10.1016/j.pmn.2022.03.001

Daniel Nicoara et al, Hyperbaric oxygen medicine suppresses withdrawal signs in morphine-dependent mice, Brain Overview (2016). DOI: 10.1016/j.brainres.2016.08.017

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Hyperbaric oxygen therapy reveals promise for opioid addiction medicine (2022, April 11)
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